Multiple Loci Mapping via Model-free Variable Selection
نویسندگان
چکیده
منابع مشابه
Multiple loci mapping via model-free variable selection.
Despite recent flourish of proposals on variable selection, genome-wide multiple loci mapping remains to be challenging. The majority of existing variable selection methods impose a model, and often the homoscedastic linear model, prior to selection. However, the true association between the phenotypical trait and the genetic markers is rarely known a priori, and the presence of epistatic inter...
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The joint action of multiple genes is an important source of variation for complex traits and human diseases. However, mapping genes with epistatic effects and gene-environment interactions is a difficult problem because of relatively small sample sizes and very large parameter spaces for quantitative trait locus models that include such interactions. Here we present a nonparametric Bayesian me...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2011
ISSN: 0006-341X
DOI: 10.1111/j.1541-0420.2011.01650.x